Manual Neuro-endocrinology of Growth and Energy Balance

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  1. Neuroendocrine integration of nutritional signals on reproduction
  2. You and Your Hormones
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  4. Frontiers | Neuroendocrine Role for VGF | Endocrinology

In fact, striking similarities between food reward and drug addiction mechanisms have been reported DiLeone et al. Therefore, these complex interactions between the homeostatic and non-homeostatic systems culminate in coordinated appetite and energy balance regulation through the modulation of endocrine, autonomic, and behavioral outputs Fig. The precise integrative mechanisms of these different levels of regulation and the generation of specific physiological outputs are among the main unsolved enigmas of the central regulation of energy balance.

Figure 2 Download Figure Download figure as PowerPoint slide Schematic integration of the different levels of food intake and energy balance regulation. Food intake and energy balance are coordinately regulated by homeostatic and non-homeostatic neural mechanisms. Circulating hormones and vagus stimuli inform the CNS about whole-body nutritional and energy status.

Leptin and insulin are believed to be involved in the long-term regulation of energy balance, while GI hormones and vagal afferents represent a short-term regulatory mechanism.


These hormones act in concert to engage specific neuronal circuits in homeostatic and hedonic centers, establishing dynamic and complex interactions between these different brain regions to elaborate coordinated endocrine, autonomic, and behavioral responses to regulate energy balance. Sensory, emotional, and social cues also influence ingestive behaviors probably through non-homeostatic and higher brain structures.

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The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the review reported. M S is a recipient of an undergraduate grant from the University of Barcelona. This work was carried out in part at the Esther Koplowitz Centre, Barcelona.

Neuroendocrine integration of nutritional signals on reproduction

Endocrinology — Brain Research — Gastroenterology 89 — Pharmacology Biochemistry and Behavior 72 — Cell Metabolism 10 — Journal of Neuroscience Methods — Nature Neuroscience 14 — Nature — Bagdade JD Bierman EL Porte D Jr The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. Journal of Clinical Investigation 46 — Neuron 42 — Cell — Journal of Clinical Investigation — PNAS 94 — Nature Reviews. Endocrinology 7 — Cell Metabolism 4 — A mechanism for regulated insulin delivery to the brain.

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  8. Journal of Clinical Investigation 92 — Cell Metabolism 7 — Journal of Neuroscience 22 — Berthoud HR Metabolic and hedonic drives in the neural control of appetite: who is the boss? Current Opinion in Neurobiology 21 — American Journal of Physiology. Peptides 29 — Neuropeptides 42 19 — Bolborea M Dale N Hypothalamic tanycytes: potential roles in the control of feeding and energy balance. Trends in Neurosciences 36 91 — Broadwell RD Brightman MW Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood.

    Journal of Comparative Neurology — PNAS 95 — Biochemical and Biophysical Research Communications — Cell Metabolism 13 — Cell 84 — Cheunsuang O Morris R Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors. Glia 52 — Diabetes 60 — New England Journal of Medicine — Hormone and Metabolic Research 45 — Neuroscience Letters 70 17 — Neuron 37 — Regulatory Peptides 1 — 6. Molecular and Cellular Biology 24 — Endocrinology and Metabolism E — E Cell Metabolism 16 — Journal of Neurobiology 60 — Trends in Neurosciences 36 65 — Nature Neuroscience 15 — American Journal of Physiology R — R Neuron 21 — Neuron 23 — Journal of Neuroscience 29 — Nature Neuroscience 7 — Farooqi IS Monogenic human obesity.

    Frontiers of Hormone Research 36 1 — Diabetes 52 — Journal of Neuroscience 20 — Journal of Neurochemistry 60 — Journal of Physiology — Synapse 1 25 — American Journal of Clinical Nutrition 30 — Journal of Comparative and Physiological Psychology 84 — Gil K Bugajski A Thor P Electrical vagus nerve stimulation decreases food consumption and weight gain in rats fed a high-fat diet. Journal of Physiology and Pharmacology 62 — Nature Genetics 17 — Molecular Endocrinology 27 — Nature Neuroscience 8 — Neuroreport 9 — PNAS — Science — Diabetes 48 — Haskell-Luevano C Monck EK Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor.

    Regulatory Peptides 99 1 — 7. Havrankova J Roth J Brownstein M Insulin receptors are widely distributed in the central nervous system of the rat. Hayes MR Skibicka KP Grill HJ Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation.

    Journal of Neuroendocrinology 24 — Cell Metabolism 11 — Brain — Peptides 30 — Cell 88 — Journal of Applied Physiology — PNAS 88 — Diabetes 50 — Diabetes 49 — American Journal of Clinical Nutrition 34 — Nature Medicine 12 — Cell Metabolism 5 — Lancet 2 — Nature 72 — Journal of Physiology and Pharmacology 52 — Nature Genetics 19 — Cell Metabolism 17 — Cell Metabolism 3 — Nature Cell Biology 14 — Diabetes 59 — Nature Medicine 16 — Peptides 28 — PNAS 96 — PNAS 99 — Diabetes 61 — American Journal of Physiology R23 — R Frontiers in Neuroscience 7 Mizuno TM Mobbs CV Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting.

    Diabetes 47 — Peptides 26 — Molecular Endocrinology 15 — Neuropeptides 9 — Recent Progress in Hormone Research 53 — Recent Progress in Hormone Research 57 19 — Neuroendocrinology 96 — Journal of Neuroscience 18 — Journal of Perinatal Medicine 38 — Nature Medicine 15 — Peptides 7 — Molecular and Cellular Biology 22 — Journal of Neuroscience 30 — Richard D Baraboi D Circuitries involved in the control of energy homeostasis and the hypothalamic—pituitary—adrenal axis activity. Treatments in Endocrinology 3 — Neuron 41 — Cell 92 — Sawchenko PE Swanson LW Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat.

    Molecular Metabolism 2 74 — Diabetes 45 — Diabetes 46 — Journal of Neuroendocrinology 17 — Journal of Neuroscience 25 — Diabetes 44 — Skibicka KP Grill HJ a Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors. Skibicka KP Grill HJ b Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins.

    Acta Neuropathologica 7 — Trends in Neurosciences 36 — Sternson SM Hypothalamic survival circuits: blueprints for purposive behaviors. Neuron 77 — Journal of Neuroendocrinology 23 — Tatemoto K Mutt V Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides. Frontiers in Neuroendocrinology 31 79 — Tolle V Low MJ In vivo evidence for inverse agonism of agouti-related peptide in the central nervous system of proopiomelanocortin-deficient mice.

    Diabetes 57 86 — Nature Neuroscience 11 — Annual Review of Physiology 68 — Nature 69 — Neuron 71 — Neuroendocrinology 70 — Peptides 22 — Journal of Clinical Endocrinology and Metabolism 86 European Journal of Pharmacology 21 — Nature Neuroscience 6 — PLoS Biology 3 e Endocrinology 72 — Nature Medicine 5 — Journal of Neuroscience 33 — Neuroscience 43 — This paper is one of four papers that form part of a thematic review section on Energy, Insulin Resistance and Metabolic Syndrome.

    Introduction The regulation of appetite and body weight is an intricate process controlled by redundant and distributed neural systems that integrate a myriad of cognitive, hedonic, emotional, and homeostatic cues to precisely regulate systemic energy balance through behavioral, autonomic, and endocrine outputs. The homeostatic system: hypothalamus and brainstem The hypothalamus: neuronal anatomy, nuclei, and neuropeptides Seminal lesioning studies conducted in rodents during the s and s highlighted the importance of the hypothalamus in the regulation of body weight.

    Lateral hypothalamus area The LHA plays a critical role in the mediation of orexigenic responses, a function that can be significantly attributed to orexin and melanin-concentrating hormone MCH neurons. Dorsomedial nucleus The DMN is involved in a range of physiological processes, including appetite, thermoregulation, stress, and circadian rhythms. The brainstem Brainstem neurons make key contributions to the control of energy balance by processing energy status information at four different levels: i by sensing circulating metabolites and hormones released by peripheral organs; ii by receiving vagal inputs from the gastrointestinal GI tract; iii by receiving neuronal inputs from midbrain and forebrain nuclei that also detect and integrate energy-related signals; and iv by projecting into local brainstem circuits and other regions of the brain to provide information that will be integrated by these neurons to control energy balance.

    Hormonal signals involved in energy homeostasis control Peripheral adiposity signals: leptin and insulin The discovery of leptin, the product of the Ob gene, in Zhang et al. GI hormones Ghrelin is a amino acid acylated hormone, mainly produced by the stomach, which exerts its biological actions on energy balance through the growth hormone secretagogue receptor GHSR; Kojima et al.

    You and Your Hormones

    Neural circuits regulating homeostatic energy balance Certain physiological conditions, such as the prandial state, are associated with notable changes in the circulating concentration of metabolites and hormones involved in the regulation of whole-body energy homeostasis. Correlating neuronal circuit activity with behavioral responses by pharmacogenetic and optogenetic techniques Most of the experimental findings that have allowed researchers to outline the models suggested so far are largely the result of circumstantial evidence.

    New players in energy balance control Non-neuronal cell types: macroglia and microglia Glial cells have traditionally been considered satellite neuronal partners with supportive and structural roles. Epigenetic mechanisms The interplay between genetic and environmental factors nutrition, maternal health, chemicals, lifestyle, etc. Concluding remarks: neuronal circuitry integration and physiological responses As has been outlined above, organismal energy balance is regulated by many factors through complex and multi-level integration processes that involve multiple neuronal circuits.

    Declaration of interest The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the review reported. Pharmacology, Biochemistry, and Behavior 72 — CO; false.

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    Frontiers | Neuroendocrine Role for VGF | Endocrinology

    Mesaros et al. Iskandar et al. Controls production of sex hormones estrogen in women and testosterone in men and the production of eggs in women and sperm in men. Controls blood pressure, both directly and also by regulating aldosterone production from the adrenal glands. Affects development of female sexual characteristics and reproductive development, important for functioning of uterus and breasts; also protects bone health.

    Health Home Conditions and Diseases. Hormones and the Endocrine System Facebook Twitter Linkedin Pinterest Print Endocrine System Adrenal Gland Procedures The endocrine system uses hormones to control and coordinate your body's internal metabolism or homeostasis energy level, reproduction, growth and development, and response to injury, stress, and environmental factors.

    Affects growth and development; stimulates protein production; affects fat distribution.